دانلود رایگان مقاله انگلیسی ویژگی های تشکیل حافظه مرتبط با ترس در موش های مبتلا به افسردگی - اشپرینگر 2018

عنوان فارسی
ویژگی های تشکیل حافظه مرتبط با ترس در موش هایی که افسردگی و فنوتیپ شبیه به اسکیزوفرنی دارند: اثرات جنسیت و سن
عنوان انگلیسی
Characteristics of the Formation of Memories Relating to Fear in Mice with Depression- and Schizophrenia-Like Phenotypes: Effects of Gender and Age
صفحات مقاله فارسی
0
صفحات مقاله انگلیسی
8
سال انتشار
2018
نشریه
اشپرینگر - Springer
فرمت مقاله انگلیسی
PDF
نوع مقاله
ISI
پایگاه
اسکوپوس
کد محصول
E10539
رشته های مرتبط با این مقاله
پزشکی، روانشناسی
گرایش های مرتبط با این مقاله
روانشناسی بالینی، روانشناسی عمومی
مجله
علوم اعصاب و فیزیولوژی رفتاری - Neuroscience and Behavioral Physiology
دانشگاه
Research Institute of Physiology and Basic Medicine - Novosibirsk - Russia
کلمات کلیدی
ترس حافظه، واکنش اجتنابی غیرفعال، سن، اختلالات جنسیتی، DISC1-Q31L، DISC1- L100P و C57Bl / 6NCr1 موش
doi یا شناسه دیجیتال
https://doi.org/10.1007/s11055-018-0590-8
چکیده

We report here a comparative analysis of the acquisition of a conditioned passive avoidance reaction in mice of the mutant strains DISC1-Q31L and DISC1-L100P and mice of the control strain C57Bl/6NCr1 and detection of the effects of gender and age on learning. DISC1-L100P mice showed impairments to associative learning to avoid the dangerous dark sector of the apparatus regardless of gender and age. In DISC1-Q31L mice, the fear memory trace formed only in young males. A defi cit of aversive learning was demonstrated in old mice of all the strains tested, with identically lower levels of learning ability in female DISC1-Q31L and C57Bl/6NCr1 mice than males. These characteristics of learning avoidance provide an additional argument for regarding DISC1-L100P mice as a genetic model of a schizophrenia-like state and DISC1-Q31L mice as a model of a depression-like state.

بحث

Discussion


Thus, the data presented here provide evidence of differences in the acquisition of a conditioned passive avoidance reaction in DISC1-Q31L and DISC1-L100P mice as compared with mice of the C57Bl/6NCr1 control group. Among the characteristics of fear memory trace formation, we draw attention to: 1) unlike control mice and DISC1-Q31L mice, DISC1-L100P mice showed genderand age-independent impairment to associative learning to avoid the dark sector of the apparatus which had become dangerous after pain punishment; 2) learning was seen only in young males among DISC1-Q31L mice, while memory traces formed in control animals in both young males and young females; 3) there were identical statistically signifi - cantly decreases in learning passive avoidance with age in male DISC1-Q31L mice and control C57Bl/6NCr1 mice, while females of these strains showed tendencies to learning defi cits. It is important to note that our results on learning defi - cit in DISC1-L100P mice are consistent with data reported from other investigations detecting learning defi cit in a contextual conditioned fear reaction in DBA/2J mice, which are regarded as a genetic model of a schizophrenia-like state [7, 38, 40, 41], and rats in a pharmacological model of this behavior [6]. Along with data on the behavioral status of DISC1-L100P mice [8, 27], this is supported by the view of DISC1-L100P mice as a genetic model of a schizophrenia-like state and widens our understanding of the role of the fear memory formation.


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